The NovaSeq 6000Dx instrument marks the beginning of a new era in the clinical laboratory. It can generate over 6 TB of data in less than two days and offers high-throughput, powerful and flexible next-generation sequencing (NGS) on a Food and Drug Administration (FDA)-regulated and Conformité Européenne (CE)-marked platform for in vitro diagnostic (IVD) applications. With a unified user interface that enables seamless control of IVD and RUO modes and a dedicated DRAGEN server for accelerated data analysis, the NovaSeq 6000Dx instrument delivers high-quality results for both clinical and research applications.